![]() Prevalence and socioeconomic impact of depressive disorders in India: multisite population-based cross-sectional study. Global burden of disease attributable to mental and substance use disorders: findings from the global burden of disease study 2010. Whiteford HA, Degenhardt L, Rehm J, et al. ![]() Findings from the global burden of disease study 2017. Institute for Health Metrics and Evaluation (IHME). ![]() International health services cardiology diabetes & endocrinology mental health primary care. Future collaborative care interventions would likely benefit from involving ASHA workers in community outreach efforts. ![]() ASHA workers' beliefs and knowledge regarding mental illness can be changed, and ASHAs can become effective advocates for patients. ASHA workers help maintain relationships with patients that encourage participation, and the efforts of ASHAs often aid in mitigating common barriers to treatment. This paper discusses the perspectives of ASHAs who participated in a novel effort to extend the collaborative care model to their own communities. Overall, ASHAs viewed the HOPE study as a necessary and effective intervention, and requested that it expand. Several expressed interest in receiving additional mental health training. ASHAs claimed that their knowledge about mental illness improved because of the HOPE study, though gaps remained in their understanding of aetiology and treatment. ASHA workers were able to identify key barriers to treatment and facilitators to treatment. ASHAs were included if they had previously participated in the HOPE intervention, a collaborative-care randomised controlled trial that aimed to integrate mental healthcare into existing primary care systems in rural Karnataka.ĪSHA workers mostly had positive interactions with patients, including encouraging them to attend sessions, helping to explain the topics and techniques, and checking on the patients frequently. ASHAs are high school-educated village women trained as community health workers. All PHCs had previously completed the HOPE study.ġ5 ASHA workers, selected via purposive sampling. Seven primary health centres (PHCs) in rural Karnataka, India. Semi-structured, one-on-one, qualitative interviews. As such, this work opens up new possibilities for employing 2D materials for targeted chemotherapeutic applications.The main objective of this exploratory study was to investigate the overlooked perspectives and beliefs of Accredited Social Health Activists (ASHA workers) regarding a collaborative care mental health intervention (HOPE: Healthier Options through Empowerment), mental illness and the health of their rural communities. From these targeted 2D NCs, the drug could release only slowly at the physiological pH but liberated rapidly at lower pH encountered by the tumor microenvironment resulting in significant toxicity toward the lung carcinoma cells. The biotinylated rGONC further improved their targetability to A549 human lung carcinoma cells and they enhanced cellular internalization efficiency. Interestingly, the antioxidant nature of GA also reduced GO to a high-quality few-layered thin reduced-graphene oxide ( rGO) during drug loading while forming rGO nanocarrier ( rGONC). To investigate such potential benefits of 2D materials, we have developed a biocompatible targeted 2D drug delivery system using graphene oxide (GO) as a model nanocarrier (NC) that could hold a high concentration of gallic acid (GA), a natural chemotherapeutic agent found in green tea. The layered structure of two-dimensional (2D) materials offers new opportunities by increasing the drug pay-load influencing the drug-release kinetics in a cancer micro-environment and facilitating targetability through the large accessible surface area. Despite the clinical availability of a large number of chemotherapeutic agents, the uncontrolled systemic distribution and the associated harmful side effects of chemotherapeutic agents pose major challenges demanding concerted efforts to enhance their cancer targetability. Chemotherapy has remained one of the most commonly employed treatment modalities for cancer.
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